The platelet-fibrinogen interaction. Evidence for proximity of the Aalpha chain of fibrinogen to platelet membrane glycoproteins IIb/III
نویسندگان
چکیده
منابع مشابه
Evidence for interaction between platelet fibrinogen receptors.
Previous analysis of fibrinogen binding to human aspirin-treated gel-filtered platelets yielded upwardly concave Scatchard plots. To ascertain whether this was due to the presence of independent heterogeneous receptor populations binding fibrinogen with different affinities, the dissociation of purified 125I-fibrinogen from ADP-treated gel-filtered platelets was evaluated as a function of recep...
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Congenital absence of platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) results in a severe bleeding disorder characterized by defective platelet aggregation and failure of fibrinogen to bind to platelets. GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. GPIIb and GPIIIa are present as a heterodimeric, noncovalent complex in the platelet plasma membrane and...
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Human plasma fibrinogen is produced by liver parenchymal cells. Such molecules contain two classes of gamma-chains (gamma A, gamma'), which differ with respect to their COOH-terminal sequences. When fibrin is crosslinked in the presence of factor XIIIa and Ca2+, three types of gamma-dimer are formed (gamma A-gamma A; gamma A-gamma'; gamma'-gamma'). A separate fibrinogen pool is located in plate...
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A unique. intrinsic. hereditary canine platelet disorder attributable to abnormal fibrinogen receptor availability is described. Thrombopathic platelets from 1 3 severely affected basset hounds failed to aggregate in response to all agonists tested except thrombin. Normal platelet interaction with the various stimuli was inferred on the basis of their ability to elicit unimpaired shape change i...
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1)orttl circulation and to involve 1)0th the liver amid spleen. \\Then isoto1W technic of I)lttelet tagging vere combined with the technics of platelet transfusions, a secoiid example of I)l(ttelet sequestration was found to occur during the first few post-transfusion hours.5 The (luration of this sequestration varies from 3 to 24 hours, and the proportion of platelets involved varied from 20 t...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1984
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1984.tb07968.x